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ADAPT Children's Eczema Study

The ADAPTrial: a clinical study to find a treatment for severe eczema in children and adolescents started in November 2014 and is now looking for volunteers.

As we all know, eczema can have a serious impact on both the child and their family, with constant itching and disturbed sleep. Some children have such severe eczema that the usual treatments do not help them.

Children whose eczema is not controlled by applying creams to the skin may need other medicines and may be able to take part in this study.

IgE is a molecule produced by the body's immune system in children with allergies. It may be important in contributing to eczema in children. The aim of this study is to use the drug, anti-IgE (Xolair or omalizumab), to neutralise and reduce the levels of IgE in children and improve their eczema.

The aims are to relieve the symptoms of eczema and reduce the amount of other treatment that these children need.

The ADAPT Children's Eczema Study team are located on 'Snowy Owl Ward' in the Evelina Children's Hospital, on the grounds of St Thomas' Hospital in London. They comprise:

Professor Gideon Lack, Professor of Paediatric Allergy, Kings College London; Dr Susan Chan, Biomedical Research Centre Clinical Research Consultant in Paediatric Allergy, Dr Emma Wedgeworth, Consultant Paediatric Dermatologist, St John's Institute of Dermatology and Dr Victoria Cornelius, Senior Lecturer in Medical Statistics at King’s College London.

Who can take part in the study?

Children and adolescents aged 4-19 years old may be suitable if they have severe eczema which has not responded to routine treatment.

What are a parent's responsibilities during the study?

The greatest responsibility for parents/ guardians is to help ensure that their child carries out the required intervention throughout the study. This means helping their child attend their appointments, using their treatments at home, and monitoring their eczema in conjunction with the health care professionals.

How to get further information and get involved?

The telephone number for participants is: 020 7188 9523/4 or you can email: ADAPT@gstt.nhs.uk.

Alternatively, you can also explore the ADAPTrial website at www.adaptrial.com.

ADAPT Children's Eczema Study...